Biological Relevance & Therapeutic Applications of DNA- & RNA-Quadruplexes
Part of the Pharmaceutical Science and Technology eBook Collection
Edited by David Monchaud
On the sixtieth anniversary of the discover by Watson, Crick, Wilkins and Franklin of the DNA double helix, a long 15-year quest finally provided solid and reliable evidence that DNA can adopt an alternative secondary architecture in cells: a structure that deviates from the canonical duplex-DNA model in that it comprises not two but four self-assembled DNA strands, thus forming a quadruple helix more frequently referred to as quadruplex-DNA. This book encompasses the many technical facets of this scientific adventure, each of them discussed by eminent researchers from the field. The book has two aims: firstly, to explain the crucial background issues, such what a quadruplex is, the structure, formation, location and function; secondly, to provide a precise roadmap that will enable the reader to fathom the ins and outs of this rapidly evolving research area.