Key Information

Price: £155

EISBN: 978-1-78084-441-1

Edited by Giampietro Corradin & Howard Engers

Overview

The quest for an effective malaria vaccine started in 1973 with a proof-of-concept study in humans protected after vaccination with whole sporozoites via mosquito bites from irradiated, infected mosquitoes. In subsequent years, however, progress has been less than anticipated. In this book of nine chapters, international expert authors review the current status of malaria vaccine development and provide some explanations as to why the progress has been somewhat disappointing. They present various improved or alternate strategies that could lead to an enhanced global collaboration and the eventual availability of an efficacious, cost-effective malaria vaccine for use in African children.

Chapters

  1. Malaria vaccines: reflections on 40 years of basic research and translation applications
    Giampietro Corradin
  2. Challenges for the stakeholders
    Howard Engers
  3. Plasmodium vivax vaccine surrogate markers of protection: dawning of a new era
    Mary R Galinski, Rabindra M Tirouvanziam & Alberto Moreno
  4. Plasmodium vivax vaccine development in Colombia: advances and challenges
    Myriam Arevalo-Herrera & Sócrates Herrera-Valencia
  5. Progress towards development of a vaccine for Plasmodium vivax malaria
    Ahmad Rushdi Shakri & Chetan E Chitnis
  6. Correlates of protection for Plasmodium falciparum malaria vaccine development: current knowledge and future research
    James G Beeson, Freya JI Fowkes, Linda Reiling, Faith H Osier, Damien R Drew & Graham V Brown
  7. Plasmodium falciparum RTS,S vaccines and future development
    Tom Egwang
  8. Plasmodium falciparum pre-erythrocytic vaccines: previous experience and the challenge of selecting new candidates
    Thomas L Richie & Joanne M Lumsden
  9. Plasmodium falciparum whole-parasite malaria vaccines
    Else M Bijker & Robert W Sauerwein