Key Information

Price: £155

EISBN: 978-1-78084-474-9

Edited by Robyn Guymer and Chi Luu

Overview

This book brings together the history of our understanding of the disease and its treatments, and brings us to today, where we are on the cusp of major advances in the understanding of this devastating disease and its potential treatments. This book initially addresses the classification of the disease with its signs and symptoms, and then summarizes the current knowledge of epidemiology, risk factors and genetic predisposition. The book then addresses the novel approaches to multimodal imaging of the macula and modern techniques used for testing retinal function. Treatments are then discussed, both highlighting the first treatments tried in neovascular AMD before anti-VEGF treatment became widespread, and then detailing the anti-VEGF era. Novel approaches to treat AMD are highlighted, including interventions that will probably have an impact on other blinding diseases such as stem cell therapy treatments and gene replacement. Finally, the impact of AMD on quality of life is discussed, and a subset of AMD called polypoidal choroidal vasculopathy is highlighted, as it appears to be a distinct subgroup and more common than initially realized. It may have different risk factors and response to treatments compared with more typical AMD.

Chapters

1. Age-related macular degeneration
   Robyn Guymer, Chi Luu
2. Classification of age-related macular degeneration
   George Trichonas, Peter K Kaiser
3. Clinical symptoms and signs
   Samir Khandhadia, Andrew J Lotery
4. Pathological insight into age-related macular degeneration including polypoidal choroidal vasculopathy
   Hiroyuki Nakashizuka
5. Epidemiology and risk factors of age-related macular degeneration
   Loren Jack, Eyal Margalit
6. Genetic markers for age-related macular degeneration
   Chee Wai Wong, Ching-Yu Cheng
7. Imaging in age-related macular degeneration
   Oudy Semoun, Eric H Souied
8. Assessment and monitoring of retinal function in age-related macular degeneration
   Chi Luu, Robyn Guymer
9. Treatment of age-related macular degeneration with laser photocoagulation and photodynamic therapy
   Michael W Stewart
10. Pharmacotherapy for neovascular age-related macular degeneration
    Irene M Rusu, Jesse J Jung, Sarah Mrejen, Roberto Gallego-Pinazo, K Bailey Freund
11. Novel approaches to restore vision in end-stage age-related macular degeneration
    Mandeep S Singh, Samantha R de Silva
12. Impact on quality of life
    Paolo Lanzetta, Daniele Veritti, Valentina Sarao
13. Polypoidal choroidal vasculopathy
    Gemmy Cheung, Gavin Tan